Endothelial cells

Tubular
epithelial cells

Podocytes

Mesangial cells

eGFR

Blood pressure

Proteinuria

Body Mass Index

8%

27%

46%

63%

Glomeruli,
extracellular matrix,
hemodynamic effect

Interstitial
compartment,
glomeruli,
hemodynamic
effect

Extracellular
matrix, interstitial
compartment,
negative
cumulative effect

Glomeruli,
extracellular
matrix, negative
cumulative effect

0.3g/day

0.5g/day

0.75g/day

1g/day